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Licensee Programmes

PRODUCT

PRECLINICAL

PHASE 1

PHASE 2

PHASE 3

Diabetology Oral Programs: Clinical Progress

Capsulin™ Oral Insulin OAD*

Preparing for Phase 3

Capsulin™ Oral Insulin IR**

12-week study in completion

Oraglutide™ Oral Weekly GLP1 RA

12-week study commenced

Satietyde™: Microdosing Daily Oraglutide for Dropouts and Maintenance Therapy

Preparing for Phase 2 based on Oraglutide data

Oral Fusion GIP/GLP1 Once Weekly POC

IVGTT Human Proof of Concept study

Capsuglutide™: Capsulin™ / Oraglutide™ combination

Preparing for clinic

Capsulin™ / small molecule

Tested in animal models

Oral GLP-1 / GIP combination

Preparing for animal studies

Oral GLP-1 / Gut hormone combination

Preparing for animal studies

Oral Obesity Triagonist peptides

Preparing for animal studies

Potentional Oral Delivery of Third-party Therapeutics (API)

Oral delivery of marketed macromolecules

Oral delivery of development macromolecules

Potentional combination therapies

* OAD is Oral Anti Diabetic agent for treatment of T2DM – improves glycaemic control and compliance and reduces side effects

** IR is an Oral Insulin Replacement for treatment of T1DM – reduces insulinaemia and improves glycaemic control

PRODUCT

PRECLINICAL

PHASE 1

PHASE 2

PHASE 3

Axcess Internal Oral Programs: Clinical Progress

Oral Calcitonin

End of Phase 2

Oral Parathyroid Hormone

Phase 2A Completed

Oral Human Growth Hormone

Available for clinic

Oral C-Peptide

Available for clinic

Oral Antibody

In research

Capsulin ™ - Oral Insulin

Treatment of Type 2 diabetes mellitus

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Oraglutide ™ - Oral GLP-1

Treatment of Type 2 diabetes and obesity

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Diabetes Epidemic

12-13% of global adult population (OECD)

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Obesity

6% of global population (OECD)

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Osteoporosis

1 in 3 women & 1 in 12 men over 50 have osteoporosis
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