REDEFINING
ORAL PEPTIDE THERAPEUTICS

Clinically validated platform enabling oral delivery
of peptide therapies in obesity, diabetes, and beyond

CLINICALLY VALIDATED

  • ORAL INSULIN – Capsulin™, oral delivery of human insulin preparing for Phase 3
  • WEEKLY ORAL GLP-1 – Oraglutide™, weekly oral GLP-1 RA in Phase 2
  • Microdose oral GLP-1 – Satietyde™, preparing for Phase 2
  • More than 25,000 safe human administrations

PHYSIOLOGY-TARGETED

  • Delivered via the small intestine – direct portal access to the liver and gut receptors
  • Engages the natural physiology of glucose control and satiety
  • Receptor-mediated delivery to the liver, gut and vagal pathways

PLATFORM OPTIONALITY

  • Single platform, multiple peptides – insulin, GLP-1, and combinations
  • Plug-and-play across peptides, with combination therapy capability
  • Demonstrated across insulin and GLP-1 RAs, applicable to next-gen peptides

THE PROPOSITION

One rule decides whether a peptide has daily or weekly action

It has two parts, and it is testable in a single rat study.

1

Does it bind a receptor on the way from the intestine to the bloodstream?

In practice: does the molecule carry a receptor moiety? That is what anchors it in the gut wall or portal vein or liver rather than letting it wash straight through.

2

Does it carry a lipid chain?

An acyl chain lets the peptide associate with chylomicrons and be held in the intestinal lipid-processing pathway instead of moving on.

BOTH YES

It behaves like a semaglutide

An intestinal depot effect forms, half-life about 48 hours. Apparent bioavailability in the outer circulation is low; biopotency is high. Reading the plasma PK and concluding the formulation failed is the commonest error in this field.

EITHER NO

It behaves like an exenatide

No depot. The peptide crosses transcellularly into the portal vein and goes on to the systemic circulation, with bioavailability and biopotency broadly tracking one another. High peripheral levels — which for some targets is exactly what you want.

Beyond metabolic treatment - orally delivers any peptide for any disease

Living with obesity, diabetes, osteoporosis, arthritis and other chronic disorders often means lifelong treatment – impacting not only health, but daily life.

Despite important medical progress, many therapies come with trade-offs, including tolerability challenges, inconvenience, and inconsistent adherence.

Advancing treatment approaches that better align with patient needs remains essential.

Driving the future of metabolic and other diseases

The Team Behind

Axcess is driven by a team of experienced scientists, healthcare innovators, and biotechnology professionals dedicated to improving diabetes treatment. Founded by experts in pharmaceutical research, drug delivery technologies, and healthcare entrepreneurship, the company combines strong scientific knowledge with commercial expertise. Together, the team focuses on developing innovative oral therapies that aim to transform how diabetes, obesity, cardiovascular and other diseases are managed worldwide.

Driving the future of diabetes treatment

The Team Behind

Diabetology is driven by a team of experienced scientists, healthcare innovators, and biotechnology professionals dedicated to improving diabetes treatment. Founded by experts in pharmaceutical research, drug delivery technologies, and healthcare entrepreneurship, the company combines strong scientific knowledge with commercial expertise. Together, the team focuses on developing innovative oral therapies that aim to transform how diabetes is managed worldwide.

Our Locations

Axcess Limited

Charter Place,
23/27 Seaton place,
St Helier,
Jersey JE1 1JY,
Channel Islands

Axcess (UK) Limited

The London BioScience Innovation Centre
2 Royal College Street,
London
NW1 0NH
United Kingdom

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