One rule decides whether a peptide has daily or weekly action
It has two parts, and it is testable in a single rat study.
1
Does it bind a receptor on the way from the intestine to the bloodstream?
In practice: does the molecule carry a receptor moiety? That is what anchors it in the gut wall or portal vein or liver rather than letting it wash straight through.
2
Does it carry a lipid chain?
An acyl chain lets the peptide associate with chylomicrons and be held in the intestinal lipid-processing pathway instead of moving on.
BOTH YES
It behaves like a semaglutide
An intestinal depot effect forms, half-life about 48 hours. Apparent bioavailability in the outer circulation is low; biopotency is high. Reading the plasma PK and concluding the formulation failed is the commonest error in this field.
EITHER NO
It behaves like an exenatide
No depot. The peptide crosses transcellularly into the portal vein and goes on to the systemic circulation, with bioavailability and biopotency broadly tracking one another. High peripheral levels — which for some targets is exactly what you want.
Beyond metabolic treatment - orally delivers any peptide for any disease
Living with obesity, diabetes, osteoporosis, arthritis and other chronic disorders often means lifelong treatment – impacting not only health, but daily life.
Despite important medical progress, many therapies come with trade-offs, including tolerability challenges, inconvenience, and inconsistent adherence.
Advancing treatment approaches that better align with patient needs remains essential.
Driving the future of metabolic and other diseases
The Team Behind
Axcess is driven by a team of experienced scientists, healthcare innovators, and biotechnology professionals dedicated to improving diabetes treatment. Founded by experts in pharmaceutical research, drug delivery technologies, and healthcare entrepreneurship, the company combines strong scientific knowledge with commercial expertise. Together, the team focuses on developing innovative oral therapies that aim to transform how diabetes, obesity, cardiovascular and other diseases are managed worldwide.
Diabetology is driven by a team of experienced scientists, healthcare innovators, and biotechnology professionals dedicated to improving diabetes treatment. Founded by experts in pharmaceutical research, drug delivery technologies, and healthcare entrepreneurship, the company combines strong scientific knowledge with commercial expertise. Together, the team focuses on developing innovative oral therapies that aim to transform how diabetes is managed worldwide.